Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.62 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.62 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669460 | 0.84 | KDM4E (0.55) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL7958872 | 0.82 | TPSAB1 (0.54) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL16026436 | 0.81 | NCF1 (0.57) | KMT2AMEN1KDM4ETP53LMNA | |
| SCHEMBL27800313 | 0.78 | KDM4E (0.66) | TPSAB1KMT2AMEN1KDM4EHRH3 | |
| SCHEMBL7424872 | 0.77 | TPSAB1 (0.53) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL5471150 | 0.76 | MEN1 (0.75) | TPSAB1KMT2AMEN1KDM4EHRH3 | |
| SCHEMBL14479131 | 0.76 | KDM4E (0.73) | TPSAB1KMT2AMEN1KDM4EHRH3 | |
| SCHEMBL5465071 | 0.75 | MEN1 (1.00) | TPSAB1KMT2AMEN1KDM4EHRH3 | |
| SCHEMBL28466660 | 0.75 | MEN1 (0.78) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL5474021 | 0.74 | MEN1 (0.76) | TPSAB1TPSD1TPSG1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |