Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 11/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TPSD1 | Q9BZJ3 | 7/20 | 0.51 |
| ▸ | TPSG1 | Q9NRR2 | 7/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448516 | 0.82 | TPSAB1 (0.62) | TPSAB1MEN1KMT2AKDM4ETPSD1 | |
| SCHEMBL7422609 | 0.79 | TPSAB1 (0.83) | TPSAB1TPSD1TPSG1PRSS1 | |
| SCHEMBL1669460 | 0.78 | KDM4E (0.55) | TPSAB1MEN1KMT2AKDM4ETPSD1 | |
| SCHEMBL7424872 | 0.78 | TPSAB1 (0.53) | TPSAB1MEN1KMT2AKDM4ETPSD1 | |
| SCHEMBL7094555 | 0.78 | ADRB1 (0.60) | TPSAB1MEN1KMT2ATPSD1TPSG1 | |
| SCHEMBL19212222 | 0.77 | ME2 (0.50) | MEN1KMT2ANPSR1 | |
| SCHEMBL20303650 | 0.77 | HRH3 (0.51) | MEN1KMT2AKDM4EHRH3 | |
| SCHEMBL1668904 | 0.77 | KMT2A (0.57) | TPSAB1MEN1KMT2AKDM4ETPSD1 | |
| SCHEMBL20705214 | 0.76 | CYP2C19 (0.61) | TPSAB1KMT2AKDM4E | |
| SCHEMBL27800313 | 0.75 | KDM4E (0.66) | TPSAB1MEN1KMT2AKDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |