Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CBFB | Q13951 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111089 | 0.84 | SMN1; SMN2 (0.42) | PDE5AAURKAHTR7ALDH1A1CYP3A4 | |
| SCHEMBL7455246 | 0.79 | METAP2 (0.36) | CYP19A1HTR1AHTR7HTR2BHTR5A | |
| SCHEMBL7107722 | 0.79 | TUBB4A (0.36) | CYP1A2 | |
| SCHEMBL6162726 | 0.74 | ABCG2 (0.42) | HTR2BALDH1A1CYP3A4TP53HPGD | |
| SCHEMBL4171658 | 0.74 | GPR84 (0.37) | ALDH1A1 | |
| SCHEMBL7449646 | 0.74 | LTK (0.35) | CLK4DYRK1AALDH1A1HPGDALOX15 | |
| SCHEMBL7111062 | 0.73 | CLK4 (0.38) | CLK4DYRK1ACYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL7105859 | 0.70 | CLK4 (0.35) | CLK4DYRK1ACYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL7453756 | 0.67 | CLK4 (0.40) | CLK4DYRK1ACYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL2071022 | 0.64 | ALDH1A1 (0.39) | ALDH1A1CYP3A4HPGDALOX15CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009485-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |