Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162726 | 0.81 | ABCG2 (0.42) | MAPK1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL1850720 | 0.76 | GPR84 (0.41) | GPR84MAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL7448786 | 0.74 | CLK4 (0.35) | ALDH1A1 | |
| SCHEMBL3381547 | 0.73 | GPR84 (0.39) | GPR84MAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL2071022 | 0.71 | ALDH1A1 (0.39) | GPR84MAPK1MAPTMEN1KMT2A | |
| SCHEMBL7111089 | 0.71 | SMN1; SMN2 (0.42) | MAPK1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL2072979 | 0.70 | ABCG2 (0.42) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2202477 | 0.69 | GPR84 (0.36) | GPR84MAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL7455246 | 0.69 | METAP2 (0.36) | MAPK1KDM4EALDH1A1GAA | |
| SCHEMBL7107722 | 0.69 | TUBB4A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
| EP-1945609-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007029036-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |
| EP-0151702-B1 | ALPHA-HYDROXYKETONE ACETALS | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1987-11-25 | — | — | EP | disclosed |
| EP-0048136-B1 | PROCESS FOR PREPARING ALPHA-AROMATIC GROUP SUBSTITUTED ALKANOIC ACIDS OR ESTERS THEREOF | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1986-06-11 | — | — | EP | disclosed |
| US-4539420-A | Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1985-09-03 | — | — | US | disclosed |
| EP-0151702-A2 | Alpha-hydroxyketone acetals | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1985-08-21 | — | — | EP | disclosed |
| EP-0067698-A2 | Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-12-22 | — | — | EP | disclosed |
| EP-0048136-A2 | Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | GPR84 1470/4885MAPK1 1181/4885MAP2K4 1050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.