SCHEMBL7449935

SCHEMBL7449935

COC(=O)C(N)(CC#Cc1ccccc1)S(=O)(=O)c1ccc(-c2ccc(OC)cc2)s1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 12/20 0.60
MMP2 P08253 10/20 0.60
MMP1 P03956 8/20 0.60
MMP3 P08254 7/20 0.60
MMP9 P14780 5/20 0.45
MMP8 P22894 2/20 0.44
ALDH1A1 P00352 2/20 0.39
MAPT P10636 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
HSD17B2 P37059 1/20 0.39
NPC1 O15118 2/20 0.38
KDM4E B2RXH2 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7499238 0.92 MMP13 (0.59) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7507876 0.86 MMP2 (0.60) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7502278 0.85 MMP13 (0.55) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7512865 0.82 KMT2A (0.39) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7447271 0.78 MMP2 (0.59) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7450645 0.78 MMP13 (0.44) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7502964 0.77 MMP13 (0.50) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7516820 0.77 MMP13 (0.54) MMP13MMP2MMP1MMP3MMP9
SCHEMBL7446832 0.76 F10 (0.47) ALDH1A1MAPTCYP1A2CYP3A4CYP2C9
SCHEMBL7499228 0.75 MMP2 (1.00) MMP13MMP2MMP1MMP3MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165501-A1 ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2002-01-02 EP disclosed
US-6197770-B1 ENZYME INHIBITORS; ANTIARTHRITIC AGENTS; BONE DISORDERS THE PROCTER & GAMBLE CO. 2001-03-06 US disclosed
WO-2000051975-A1 ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2000-09-08 WO disclosed