Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452045 | 0.81 | MGLL (0.54) | KMT2AMEN1LMNAL3MBTL1MAPT | |
| SCHEMBL7453246 | 0.80 | MGLL (0.53) | KMT2AMEN1LMNAL3MBTL1MAPT | |
| SCHEMBL7639184 | 0.80 | NAMPT (0.48) | KMT2AALDH1A1MEN1LMNAHPGD | |
| SCHEMBL7456487 | 0.79 | LMNA (0.42) | KMT2AALDH1A1MEN1LMNAHPGD | |
| SCHEMBL7511899 | 0.78 | KMT2A (0.58) | KMT2AALDH1A1MEN1LMNAPOLB | |
| SCHEMBL4576825 | 0.77 | EPHX2 (0.56) | KMT2AALDH1A1MEN1LMNAHPGD | |
| SCHEMBL1256120 | 0.75 | EPHX2 (0.60) | EPHX2CYP2C9CYP2J2HRH3CNR1 | |
| SCHEMBL7518460 | 0.75 | NAMPT (0.48) | KMT2AALDH1A1MEN1LMNAHPGD | |
| SCHEMBL4576854 | 0.74 | EPHX2 (0.58) | EPHX2CYP2C9CYP2J2HRH3CNR1 | |
| SCHEMBL2096831 | 0.74 | EPHX2 (0.55) | ALDH1A1HPGDEPHX2NAMPTACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455531-B1 | METALLOPROTEINASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2002-09-24 | — | — | US | disclosed |
| EP-1237868-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044189-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |