Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452045 | 0.80 | MGLL (0.54) | LMNAKMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL7636495 | 0.80 | EPHX2 (0.43) | LMNAALDH1A1GAAEPHX2SPR | |
| SCHEMBL7453246 | 0.79 | MGLL (0.53) | LMNAKMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL7450265 | 0.79 | KMT2A (0.48) | LMNAALDH1A1EPHX2KMT2AMEN1 | |
| SCHEMBL7511899 | 0.77 | KMT2A (0.58) | LMNAALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL2931624 | 0.76 | SPR (0.53) | LMNAALDH1A1EPHX2SPRKMT2A | |
| SCHEMBL7518089 | 0.75 | MMP1 (0.46) | LMNAALDH1A1GAAEPHX2SPR | |
| SCHEMBL1761034 | 0.73 | EPHX2 (0.50) | LMNAGAAEPHX2SPRKMT2A | |
| SCHEMBL7453044 | 0.72 | MGLL (0.55) | LMNAKMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL1806612 | 0.71 | CA12 (0.62) | ALDH1A1SPRKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455531-B1 | METALLOPROTEINASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2002-09-24 | — | — | US | disclosed |
| EP-1237868-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044189-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |