Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | HTR7 | P34969 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15840450 | 0.85 | KMT2A (0.61) | KMT2AMAPTMEN1HTR7HTR1A | |
| SCHEMBL7452045 | 0.79 | MGLL (0.54) | KMT2AMAPTMEN1LMNA | |
| SCHEMBL7453246 | 0.78 | MGLL (0.53) | KMT2AMAPTMEN1LMNA | |
| SCHEMBL7450265 | 0.78 | KMT2A (0.48) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7511887 | 0.77 | AKR1C3 (0.56) | KMT2AMAPTMEN1HTR7HTR1A | |
| SCHEMBL7456487 | 0.77 | LMNA (0.42) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9987526 | 0.77 | KMT2A (0.68) | KMT2AMAPTMEN1HTR7HTR1A | |
| SCHEMBL12419699 | 0.75 | AKR1C3 (0.68) | KMT2AMAPTMEN1HTR7HTR1A | |
| SCHEMBL15840436 | 0.74 | MAPT (0.69) | KMT2AMAPTMEN1HTR7HTR1A | |
| SCHEMBL2824683 | 0.74 | MAPT (1.00) | KMT2AMAPTMEN1HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455531-B1 | METALLOPROTEINASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2002-09-24 | — | — | US | disclosed |
| EP-1237868-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044189-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |