Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371836 | 0.81 | PNP (0.33) | BRD4CREBBP | |
| SCHEMBL2575471 | 0.74 | ALDH1A1 (0.46) | KDM4EALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL23074728 | 0.68 | — | — | |
| SCHEMBL29064067 | 0.66 | PGR (0.38) | — | |
| SCHEMBL5440710 | 0.64 | ALDH1A1 (0.35) | KDM4EALDH1A1USP2KMT2ACFTR | |
| SCHEMBL8877986 | 0.62 | BAZ2B (0.40) | CREBBPKDM4EALDH1A1CCNCCDK8 | |
| SCHEMBL7824673 | 0.62 | LMNA (0.39) | KDM4EALDH1A1KMT2ASMN1; SMN2PKM | |
| SCHEMBL5960581 | 0.62 | CDK8 (0.38) | BRD4CREBBPBRPF1EP300ALDH1A1 | |
| SCHEMBL4268684 | 0.62 | PRNP (0.42) | KDM4EALDH1A1CCNCCDK8KMT2A | |
| SCHEMBL11774693 | 0.62 | BRD4 (0.35) | BRD4CREBBPBRPF1EP300PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257553-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK Chemicals Co., Ltd. (KR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060825-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO., LTD. (KR) | 2001-08-23 | — | — | WO | disclosed |