Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12922856 | 0.92 | KDM4E (0.44) | GAAPOLBCA12CA9KDM4E | |
| SCHEMBL12922850 | 0.91 | KDM4E (0.44) | GAAPOLBPTPN1CA12CA9 | |
| SCHEMBL3969643 | 0.88 | KDM4E (0.42) | GAAPOLBCA12CA9KDM4E | |
| SCHEMBL3974292 | 0.87 | KDM4E (0.41) | GAAPOLBCA12CA9KDM4E | |
| SCHEMBL3974291 | 0.87 | KDM4E (0.41) | GAAPOLBPTPN1CA12CA9 | |
| SCHEMBL6939090 | 0.85 | TSHR (0.51) | PTPN1TSHRPPARGPPARAATM | |
| SCHEMBL3968940 | 0.84 | KDM4E (0.42) | GAAPOLBCA12CA9KDM4E | |
| SCHEMBL3969680 | 0.84 | KDM4E (0.42) | GAAPOLBCA12CA9KDM4E | |
| SCHEMBL12922866 | 0.83 | PTPN1 (0.47) | PTPN1TSHRPPARGPPARAATM | |
| SCHEMBL12922861 | 0.82 | CYP2A6 (0.42) | FAAHALDH1A1CYP3A4CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759376-B2 | Isoxazole and isothiazole compounds useful in the treatment of inflammation | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2014-06-24 | — | — | US | disclosed |
| US-20110015231-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | AL-ABED YOUSEF | 2011-01-20 | — | — | US | disclosed |
| US-7807696-B2 | Isoxazole and isothiazole compounds useful in the treatment of inflammation | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-10-05 | — | — | US | disclosed |
| WO-2010053162-A1 | NON-AQUEOUS ELECTROLYSIS SOLUTION CONTAINING PYRIDYL 5-MEMBERED HETEROCYCLIC DERIVATIVE, AND LITHIUM SECONDARY BATTERY | 三井化学株式会社 (JP) | 2010-05-14 | — | — | WO | disclosed |
| US-20080075728-A1 | Combination Therapies Of Hmgb And Complement Inhibitors Against Inflammation | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH | 2008-03-27 | — | — | US | disclosed |
| US-20070021465-A1 | Anti-inflammatory compounds | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | 2007-01-25 | — | — | US | disclosed |
| US-5330994-A | Antidepressants, anxiolytic agents | WARNER-LAMBERT COMPANY (US) | 1994-07-19 | — | — | US | disclosed |
| WO-1993019062-A1 | TETRAHYDROPYRIDINE ISOXAZOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080075728-A1 | Combination Therapies Of Hmgb And Complement Inhibitors Against Inflammation | HMGB2, HMGB1, HMGB3 | GAA 2760/4885POLB 1288/4885PTPN1 2968/4885 |
| US-20070021465-A1 | Anti-inflammatory compounds | IL6, IL1A, IL1B | GAA 509/4885POLB 2344/4885PTPN1 3498/4885 |
| US-20110015231-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | IL1A, IL1B, IL17A | GAA 1723/4885POLB 3410/4885PTPN1 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.