Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 3/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL7450478 | 1.00 | GRIK1 (0.40) | GRIK1GRIK2KMOSLC7A5PKM | |
| Aspartic Acid SCHEMBL7370755 | 0.81 | TXNRD1 (0.43) | GRIK1GRIK2KMOLMNACASP3 | |
| Aspartic Acid SCHEMBL7370757 | 0.81 | TXNRD1 (0.43) | GRIK1GRIK2KMOLMNACASP3 | |
| SCHEMBL3316731 | 0.81 | ALDH1A1 (0.50) | LMNAALDH1A1MAPTKDM4EHIF1A | |
| Aspartic Acid SCHEMBL7370756 | 0.79 | GRIK1 (0.41) | GRIK1GRIK2KMOCASP3CASP6 | |
| SCHEMBL12946377 | 0.75 | CASP3 (0.49) | CASP3CASP6CASP8ALDH1A1TDP1 | |
| SCHEMBL7111662 | 0.75 | TXNRD1 (0.45) | GRIK1GRIK2KMOLMNACASP3 | |
| SCHEMBL28477651 | 0.73 | ALDH1A1 (0.46) | LMNAALDH1A1MAPTKDM4EHIF1A | |
| SCHEMBL5703139 | 0.70 | ALDH1A1 (0.58) | LMNAALDH1A1MAPTTDP1POLB | |
| SCHEMBL31520067 | 0.70 | KMO (0.51) | GRIK1GRIK2KMOSLC7A5PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752987-A4 | PYRIMIDINYL DERIVATIVES AS INTERLEUKIN INHIBITORS | SANOFI WINTHROP INC (US) | 1997-04-09 | — | — | EP | disclosed |
| EP-0752987-A1 | PYRIMIDINYL DERIVATIVES AS INTERLEUKIN INHIBITORS | SANOFI WINTHROP, INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026958-A1 | PYRIMIDINYL DERIVATIVES AS INTERLEUKIN INHIBITORS | SANOFI WINTHROP, INC. (US) | 1995-10-12 | — | — | WO | disclosed |