Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 8/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457553 | 0.87 | GABRA2 (0.46) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL7454157 | 0.85 | HSD17B3 (0.44) | ALDH1A1HSD17B3HTR7HPGDHSD17B10 | |
| SCHEMBL7452821 | 0.84 | HSD17B3 (0.35) | GABRG2GABRB3GABRA5TSHRGABRA2 | |
| SCHEMBL7454502 | 0.84 | NPSR1 (0.48) | GABRG2GABRB3GABRA5GABRA2ALDH1A1 | |
| SCHEMBL7449989 | 0.83 | GLP1R (0.35) | GABRG2GABRB3GABRA5TSHRGABRA2 | |
| SCHEMBL7458456 | 0.80 | LMNA (0.45) | GABRG2GABRB3GABRA5GABRA2GABRB2 | |
| SCHEMBL7453223 | 0.80 | GABRG2 (0.45) | GABRG2GABRB3GABRA5TSHRGABRA2 | |
| SCHEMBL7454183 | 0.79 | GRM5 (0.40) | GABRG2GABRB3GABRA5TSHRGABRA2 | |
| SCHEMBL7454766 | 0.78 | GABRG2 (0.44) | GABRG2GABRB3GABRA5TSHRGABRA2 | |
| SCHEMBL3604654 | 0.75 | GLA (0.45) | GABRG2GABRB3GABRA5TSHRGABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |