Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 8/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458456 | 0.91 | LMNA (0.45) | GABRA2GABRB2GABRG2GABRB3GABRA5 | |
| SCHEMBL7450868 | 0.87 | GABRG2 (0.44) | GABRA2GABRB2GABRG2GABRB3GABRA5 | |
| SCHEMBL7453068 | 0.85 | HSD17B3 (0.44) | GABRA2GABRB2HSD17B3KMT2AMEN1 | |
| SCHEMBL7454502 | 0.84 | NPSR1 (0.48) | GABRA2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL7449989 | 0.83 | GLP1R (0.35) | GABRA2GABRB2GABRG2GABRB3GABRA5 | |
| SCHEMBL7454183 | 0.81 | GRM5 (0.40) | GABRA2GABRB2GABRG2GABRB3GABRA5 | |
| SCHEMBL7453081 | 0.80 | SLC5A1 (0.51) | GABRA2GABRB2GABRG2GABRB3GABRA5 | |
| SCHEMBL7446764 | 0.75 | GRM5 (0.52) | HSD17B3KMT2AMEN1MAPT | |
| SCHEMBL7454447 | 0.74 | SLC5A1 (0.48) | GABRA2GABRB2GABRG2GABRB3GABRA5 | |
| SCHEMBL13313 | 0.73 | NPSR1 (0.46) | GABRA2GABRB2GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |