Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.44 |
| ▸ | ITGAV | P06756 | 5/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.44 |
| ▸ | ACE | P12821 | 6/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451733 | 1.00 | FPR2 (0.45) | FPR2ITGB1ITGA4ITGB3ITGA2B | |
| SCHEMBL7376760 | 0.89 | ITGB1 (0.45) | FPR2ITGB1ITGA4ITGB3ITGA2B | |
| SCHEMBL7450957 | 0.89 | ITGB1 (0.45) | FPR2ITGB1ITGA4ITGB3ITGA2B | |
| SCHEMBL7458234 | 0.88 | ITGB1 (0.47) | FPR2ITGB1ITGA4ITGB3ITGA2B | |
| SCHEMBL7378843 | 0.88 | ITGB1 (0.47) | FPR2ITGB1ITGA4ITGB3ITGA2B | |
| SCHEMBL7451750 | 0.86 | FPR2 (0.43) | FPR2ITGB1ITGA4ITGB3ITGA2B | |
| SCHEMBL7451758 | 0.86 | FPR2 (0.43) | FPR2ITGB1ITGA4ITGB3ITGA2B | |
| SCHEMBL8428868 | 0.84 | RHOC (0.43) | FPR2ACEECE1P2RX1 | |
| SCHEMBL7451739 | 0.83 | ACE (0.45) | FPR2ITGB1ITGA4ACEECE1 | |
| SCHEMBL7449645 | 0.81 | ITGB3 (0.40) | ITGB1ITGA4ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-B1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-02-06 | — | — | EP | claimed |
| EP-1157985-A1 | Para- substituted phenylene derivatives and their use as integrin antagonists | G.D. SEARLE & CO. (US) | 2001-11-28 | — | — | EP | claimed |
| EP-0891325-B1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-02-06 | — | — | EP | disclosed |