Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 1/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375077 | 0.90 | RHOC (0.39) | RHOCRHOAPSMB5TACR1NOS3 | |
| SCHEMBL7380932 | 0.90 | RHOC (0.43) | RHOCRHOATACR1ALDH1A1NOS3 | |
| SCHEMBL7454545 | 0.84 | FPR2 (0.45) | ACEFPR2ECE1P2RX1 | |
| SCHEMBL7451733 | 0.84 | FPR2 (0.45) | ACEFPR2ECE1P2RX1 | |
| SCHEMBL7451739 | 0.84 | ACE (0.45) | RHOCRHOAPSMB5TACR1ALDH1A1 | |
| SCHEMBL7379710 | 0.81 | ITGB3 (0.41) | RHOCRHOAP2RX1MCL1 | |
| SCHEMBL7803127 | 0.77 | FPR2 (0.45) | RHOCRHOATACR1ACEFPR2 | |
| SCHEMBL7449645 | 0.76 | ITGB3 (0.40) | RHOCRHOAALDH1A1NOS3NOS1 | |
| SCHEMBL7378843 | 0.76 | ITGB1 (0.47) | ACEFPR2P2RX1 | |
| SCHEMBL7458234 | 0.76 | ITGB1 (0.47) | ACEFPR2P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |