Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.35 |
| ▸ | PARG | Q86W56 | 4/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457228 | 1.00 | HDAC6 (0.39) | HDAC6HDAC1HDAC8MAPK8P2RX3 | |
| SCHEMBL7472667 | 0.79 | TP53 (0.42) | MAPT | |
| SCHEMBL7457234 | 0.79 | HDAC6 (0.37) | HDAC6HDAC1HDAC8MAPK8P2RX3 | |
| SCHEMBL7472819 | 0.77 | HSP90AA1 (0.39) | HDAC6HDAC1HDAC8MAPK8P2RX3 | |
| SCHEMBL7559676 | 0.76 | HDAC6 (0.43) | HDAC6HDAC1HDAC8MAPK8PARG | |
| SCHEMBL7467388 | 0.75 | PSEN1 (0.42) | HDAC6HDAC1HDAC8 | |
| SCHEMBL7467037 | 0.73 | SLC1A3 (0.43) | HDAC6HDAC1HDAC8 | |
| SCHEMBL7472833 | 0.73 | MAPT (0.48) | MAPT | |
| SCHEMBL7468517 | 0.73 | HDAC6 (0.52) | HDAC6HDAC1HDAC8MAPK8MAPT | |
| SCHEMBL7461329 | 0.72 | CMA1 (0.46) | HDAC6HDAC1HDAC8MAPK8PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |