Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461329 | 0.84 | CMA1 (0.46) | HDAC6HDAC1HDAC8CMA1PARG | |
| SCHEMBL7467037 | 0.83 | SLC1A3 (0.43) | HDAC6HDAC1HDAC8CA12CA1 | |
| SCHEMBL7460713 | 0.81 | MAPK8 (0.55) | HDAC6HDAC1HDAC8CMA1MAPK8 | |
| SCHEMBL7461911 | 0.81 | MAPT (0.44) | CMA1CA12CA1CA2CA9 | |
| SCHEMBL7472833 | 0.81 | MAPT (0.48) | CMA1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7468517 | 0.81 | HDAC6 (0.52) | HDAC6HDAC1HDAC8CMA1MAPK8 | |
| SCHEMBL7466124 | 0.79 | CMA1 (0.46) | HDAC6HDAC1HDAC8CMA1PARG | |
| SCHEMBL7462052 | 0.79 | KMT2A (0.47) | HDAC6HDAC1HDAC8CMA1PARG | |
| SCHEMBL7459226 | 0.79 | PARG (0.44) | HDAC6HDAC1HDAC8CMA1PARG | |
| SCHEMBL7472590 | 0.78 | HDAC6 (0.54) | HDAC6HDAC1HDAC8CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |