Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | RHEB | Q15382 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472478 | 0.90 | CCR2 (0.50) | HDAC6HDAC1HDAC8SMN1; SMN2CMA1 | |
| SCHEMBL7472590 | 0.88 | HDAC6 (0.54) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7460713 | 0.88 | MAPK8 (0.55) | HDAC6HDAC1HDAC8SMN1; SMN2CMA1 | |
| SCHEMBL7461329 | 0.86 | CMA1 (0.46) | HDAC6HDAC1HDAC8SMN1; SMN2CMA1 | |
| SCHEMBL7471533 | 0.84 | MAPT (0.45) | SMN1; SMN2CMA1MEN1KMT2AMAPT | |
| SCHEMBL7468017 | 0.84 | HDAC6 (0.45) | HDAC6HDAC1HDAC8SMN1; SMN2CMA1 | |
| SCHEMBL7466124 | 0.84 | CMA1 (0.46) | HDAC6HDAC1HDAC8CMA1MAPK8 | |
| SCHEMBL7465874 | 0.83 | AKR1B1 (0.50) | HDAC6CMA1PSEN1PSEN2APH1B | |
| SCHEMBL7462052 | 0.83 | KMT2A (0.47) | HDAC6HDAC1HDAC8CMA1MAPK8 | |
| SCHEMBL7459226 | 0.83 | PARG (0.44) | HDAC6HDAC1HDAC8SMN1; SMN2CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |