Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467388 | 0.79 | PSEN1 (0.42) | HDAC6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7470720 | 0.78 | PSEN1 (0.43) | HDAC6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7457233 | 0.77 | HDAC6 (0.39) | HDAC6HDAC1HDAC8RORCMAPK8 | |
| SCHEMBL7457228 | 0.77 | HDAC6 (0.39) | HDAC6HDAC1HDAC8RORCMAPK8 | |
| SCHEMBL7469901 | 0.77 | CMA1 (0.44) | HDAC6PSEN1PSEN2APH1BNCSTN | |
| Bromide SCHEMBL7465782 | 0.76 | PSEN1 (0.37) | HDAC6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7472667 | 0.76 | TP53 (0.42) | POLB | |
| SCHEMBL7460713 | 0.76 | MAPK8 (0.55) | HDAC6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7472701 | 0.75 | PSEN1 (0.42) | HDAC6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7463851 | 0.75 | NOX4 (0.46) | MAPK8CMA1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |