Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 8/20 | 0.65 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3742918 | 0.90 | LIPE (0.63) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL745622 | 0.88 | LIPE (0.69) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL747576 | 0.86 | LIPE (0.66) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL13075630 | 0.86 | LIPE (0.66) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL743532 | 0.85 | LIPE (0.57) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL745034 | 0.85 | LIPE (0.60) | LIPEEGLN1CCR1 | |
| SCHEMBL743653 | 0.83 | LIPE (0.62) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL744566 | 0.83 | LIPE (0.64) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL746972 | 0.82 | LIPE (0.67) | LIPEEGLN1CCR1CTSGCMA1 | |
| SCHEMBL746095 | 0.82 | LIPE (0.59) | LIPEEGLN1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430023-B1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-12-11 | — | — | EP | claimed |
| US-20100292212-A1 | NEW AZACYCLIC DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | US | claimed |
| EP-2707371-B1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| EP-2707371-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-03-19 | — | — | EP | disclosed |
| EP-2430023-B1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-12-11 | — | — | EP | disclosed |
| US-8497288-B2 | Hexahydropyrroloimidazolone compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8329904-B2 | Azacyclic derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329904-B2 | Azacyclic derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329904-B2 | Azacyclic derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |
| WO-2012152663-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-15 | — | — | WO | disclosed |
| US-20120289549-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-15 | — | — | US | disclosed |
| EP-2430023-A1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130665-A1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292212-A1 | NEW AZACYCLIC DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289549-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | LIPC, PNLIP, LIPE | LIPE 3/4885EGLN1 1251/4885CCR1 1676/4885 |
| US-20100292212-A1 | NEW AZACYCLIC DERIVATIVES | GPR119, LDLR, LPL | LIPE 10/4885EGLN1 2307/4885CCR1 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.