Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.34 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011756 | 0.78 | BCHE (0.50) | GAAHDAC8ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL12946013 | 0.77 | CRBN (0.51) | GAACRBNDDB1HDAC8ADAMTS4 | |
| SCHEMBL6791929 | 0.77 | CRBN (0.51) | GAACRBNDDB1HDAC8ADAMTS4 | |
| SCHEMBL14357764 | 0.74 | HDAC8 (0.57) | GAACRBNDDB1HDAC8ADAMTS4 | |
| SCHEMBL1011632 | 0.74 | HDAC8 (0.57) | GAACRBNDDB1HDAC8ADAMTS4 | |
| SCHEMBL6515372 | 0.73 | GAA (0.48) | GAAADAMTS4ADAMTS5ALDH1A1MEN1 | |
| SCHEMBL15974260 | 0.71 | GAA (0.49) | GAAHDAC8ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL6791007 | 0.71 | GAA (0.49) | GAAHDAC8ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL1598100 | 0.70 | CRBN (0.49) | GAACRBNDDB1HDAC8ALDH1A1 | |
| SCHEMBL12258527 | 0.69 | HDAC8 (0.47) | GAAHDAC8ADAMTS4ADAMTS5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718290-B1 | Carboxyalkyl heterocyclic derivatives | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2002-04-17 | — | — | EP | disclosed |
| US-5912261-A | ANTIDIABETIC AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1999-06-15 | — | — | US | disclosed |
| EP-0718290-A1 | Carboxyalkyl heterocyclic derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |