Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946013 | 1.00 | CRBN (0.51) | CRBNGAAMAPTNPC1RAB9A | |
| SCHEMBL14357764 | 0.78 | HDAC8 (0.57) | CRBNGAADDB1HDAC8ADAMTS4 | |
| SCHEMBL1011632 | 0.78 | HDAC8 (0.57) | CRBNGAADDB1HDAC8ADAMTS4 | |
| SCHEMBL7457787 | 0.77 | GAA (0.43) | CRBNGAAMAPTNPC1RAB9A | |
| SCHEMBL15974260 | 0.75 | GAA (0.49) | GAAL3MBTL1HDAC8ADAMTS4ADAMTS5 | |
| SCHEMBL6791007 | 0.75 | GAA (0.49) | GAAL3MBTL1HDAC8ADAMTS4ADAMTS5 | |
| SCHEMBL14398335 | 0.74 | GAA (0.43) | CRBNGAAMAPTNPC1RAB9A | |
| SCHEMBL1598100 | 0.73 | CRBN (0.49) | CRBNGAAMAPTL3MBTL1DDB1 | |
| SCHEMBL12482199 | 0.73 | L3MBTL1 (0.50) | CRBNGAAMAPTNPC1RAB9A | |
| SCHEMBL16903961 | 0.73 | L3MBTL1 (0.50) | CRBNGAAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147573-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| US-20040110809-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-06-10 | — | — | US | disclosed |
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1370538-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074752-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
| US-5767140-A | USEFUL FOR TREATING AIDS | SOUTHERN RESEARCH INSTITUTE (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0660826-A4 | 5,5-DISUBSTITUTED HYDANTOINS. | SOUTHERN RES INST (US) | 1996-07-31 | — | — | EP | disclosed |
| EP-0660826-A1 | 5,5-DISUBSTITUTED HYDANTOINS | SOUTHERN RESEARCH INSTITUTE (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006775-A1 | 5,5-DISUBSTITUTED HYDANTOINS | SOUTHERN RESEARCH INSTITUTE (US) | 1994-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110809-A1 | Metalloproteinase inhibitors | MMP9, MMP2, MMP3 | CRBN 4722/4885GAA 274/4885MAPT 4179/4885 |
| US-20040147573-A1 | Metalloproteinase inhibitors | MMP12, MMP7, MMP10 | CRBN 2960/4885GAA 408/4885MAPT 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.