Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459393 | 0.87 | MAPK8 (0.53) | KDM4EMAPK8PKMKMT2AALDH1A1 | |
| SCHEMBL6465388 | 0.81 | KDM4E (1.00) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7452165 | 0.81 | LMNA (0.60) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7455341 | 0.79 | KDM4E (0.76) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7458478 | 0.79 | KDM4E (0.76) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7460054 | 0.77 | PKM (0.58) | PKMKMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8383136 | 0.74 | HRH3 (0.65) | KMT2AALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL24271910 | 0.74 | MAPK8 (1.00) | KDM4EMAPK8PKMKMT2ASMN1; SMN2 | |
| SCHEMBL10364805 | 0.73 | KMT2A (0.58) | KDM4EKMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6463108 | 0.72 | LMNA (0.64) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819118-B1 | POTASSIUM ION CHANNEL BLOCKERS | POLYCHIP PHARMACEUTICALS PTY (AU) | 2002-09-18 | — | — | EP | disclosed |
| US-5929082-A | SULFONYL(THIO)UREA AND SULFONYLGUANIDINE COMPOUNDS; TREATMENT OF DIABETES, CARDIAC ARRHYTHMIAS, ISCHEMIA, HYPOXIC CARDIOVASCUALR DISORDERS AND CANCER | POLYCHIP PHARMACEUTICALS PTY LTD (AU) | 1999-07-27 | — | — | US | disclosed |
| EP-0819118-A4 | POTASSIUM ION CHANNEL BLOCKERS | POLYCHIP PHARMACEUTICALS PTY (AU) | 1998-04-29 | — | — | EP | disclosed |
| EP-0819118-A1 | POTASSIUM ION CHANNEL BLOCKERS | Polychip Pharmaceuticals Pty. Ltd. (AU) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996030341-A1 | POTASSIUM ION CHANNEL BLOCKERS | POLYCHIP PHARMACEUTICALS PTY. LTD. (AU) | 1996-10-03 | — | — | WO | disclosed |