Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459203 | 0.87 | KDM4E (0.68) | MAPK8ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL7459723 | 0.80 | KDM4E (0.56) | ALDH1A1KDM4EPPARGPTGS1PTGS2 | |
| SCHEMBL7454603 | 0.80 | KDM4E (0.56) | ALDH1A1KDM4EPPARGPTGS1PTGS2 | |
| SCHEMBL7460595 | 0.77 | ALDH1A1 (0.51) | ALDH1A1PPARGMAPTGAAKCNH2 | |
| SCHEMBL7455253 | 0.77 | PTGS2 (0.58) | ALDH1A1KDM4EPPARGPTGS2MAPT | |
| SCHEMBL7297544 | 0.72 | ALDH1A1 (0.52) | ALDH1A1KDM4EPPARGPTGS1PTGS2 | |
| SCHEMBL7452165 | 0.71 | LMNA (0.60) | ALDH1A1KDM4EPPARGPKMKMT2A | |
| SCHEMBL24271910 | 0.70 | MAPK8 (1.00) | MAPK8KDM4EMAPTPKMKMT2A | |
| SCHEMBL5186788 | 0.69 | ALDH1A1 (0.74) | ALDH1A1KDM4EPPARGMAPTGAA | |
| SCHEMBL7461770 | 0.69 | ALDH1A1 (0.55) | ALDH1A1KDM4EPTGS2GAAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819118-B1 | POTASSIUM ION CHANNEL BLOCKERS | POLYCHIP PHARMACEUTICALS PTY (AU) | 2002-09-18 | — | — | EP | disclosed |
| US-5929082-A | SULFONYL(THIO)UREA AND SULFONYLGUANIDINE COMPOUNDS; TREATMENT OF DIABETES, CARDIAC ARRHYTHMIAS, ISCHEMIA, HYPOXIC CARDIOVASCUALR DISORDERS AND CANCER | POLYCHIP PHARMACEUTICALS PTY LTD (AU) | 1999-07-27 | — | — | US | disclosed |
| EP-0819118-A4 | POTASSIUM ION CHANNEL BLOCKERS | POLYCHIP PHARMACEUTICALS PTY (AU) | 1998-04-29 | — | — | EP | disclosed |
| EP-0819118-A1 | POTASSIUM ION CHANNEL BLOCKERS | Polychip Pharmaceuticals Pty. Ltd. (AU) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996030341-A1 | POTASSIUM ION CHANNEL BLOCKERS | POLYCHIP PHARMACEUTICALS PTY. LTD. (AU) | 1996-10-03 | — | — | WO | disclosed |