SCHEMBL7460149

SCHEMBL7460149

Cc1c(Cl)cc2nccc(Oc3ccc(F)cc3)c2c1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RET P07949 2/20 0.42
MET P08581 6/20 0.41
AXL P30530 5/20 0.41
MERTK Q12866 2/20 0.41
KDR P35968 4/20 0.41
PDGFRA P16234 3/20 0.41
CCNC P24863 1/20 0.38
CDK8 P49336 1/20 0.38
TRPA1 O75762 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
AURKA O14965 1/20 0.37
RIPK2 O43353 1/20 0.37
ABCB11 O95342 1/20 0.37
ABL1 P00519 1/20 0.37
EGFR P00533 1/20 0.37
ERBB2 P04626 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoxyfen SCHEMBL28247243 0.80 RET (0.42) RETMETAXLMERTKKDR
Quinoxyfen SCHEMBL22257 0.80 RET (0.42) RETMETAXLMERTKKDR
Quinoxyfen SCHEMBL1974400 0.78 RET (0.41) RETMETAXLMERTKKDR
Quinoxyfen SCHEMBL7471425 0.78 RET (0.41) RETMETAXLMERTKKDR
SCHEMBL7463159 0.77 RET (0.44) RETMETAXLMERTKKDR
SCHEMBL27313912 0.75 L3MBTL1 (0.40) RETMETAXLMERTKKDR
SCHEMBL7467913 0.74 PDGFRA (0.63) RETMETAXLMERTKKDR
Quinoxyfen SCHEMBL28210064 0.73 RET (0.40) RETMETAXLMERTKKDR
SCHEMBL7470310 0.73 MAOA (0.38) RETMETAXLMERTKKDR
SCHEMBL14285766 0.71 RET (0.44) RETMETAXLMERTKKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP disclosed