Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | NEK2 | P51955 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463154 | 1.00 | MCL1 (0.53) | MCL1KDM4EMAPTGAANEK2 | |
| SCHEMBL7467178 | 0.80 | KMT2A (0.56) | KDM4EMAPTNPC1RAB9AEGFR | |
| SCHEMBL7461493 | 0.77 | MAPT (0.48) | KDM4EMAPTGAANPC1RAB9A | |
| SCHEMBL7470135 | 0.77 | LMNA (0.62) | MCL1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL25670655 | 0.76 | MCL1 (0.58) | MCL1KDM4EMAPTGAANEK2 | |
| SCHEMBL7461370 | 0.76 | ALDH1A1 (0.59) | KDM4EMAPTGAARAB9AEGFR | |
| SCHEMBL23171576 | 0.75 | MCL1 (0.54) | MCL1KDM4EMAPTGAANEK2 | |
| SCHEMBL27837846 | 0.75 | PLAU (0.47) | KDM4EGAANPC1RAB9AALDH1A1 | |
| SCHEMBL7470342 | 0.75 | MEN1 (0.60) | KDM4EMAPTRAB9AEGFRALDH1A1 | |
| SCHEMBL1388796 | 0.75 | MCL1 (0.66) | MCL1KDM4EMAPTGAANEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | claimed |
| EP-0700388-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-03-13 | — | — | EP | claimed |
| WO-1995026341-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-10-05 | — | — | WO | claimed |
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-5652250-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1997-07-29 | — | — | US | disclosed |
| EP-0700388-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-03-13 | — | — | EP | disclosed |
| WO-1995026341-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-10-05 | — | — | WO | disclosed |