Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.62 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.62 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.62 |
| ▸ | USP9X | Q93008 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | EEF2K | O00418 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | AXL | P30530 | 1/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470342 | 0.92 | MEN1 (0.60) | LMNAPLIN1PLIN5ABHD5USP9X | |
| SCHEMBL7461370 | 0.89 | ALDH1A1 (0.59) | LMNAPLIN1PLIN5ABHD5USP9X | |
| SCHEMBL7467178 | 0.82 | KMT2A (0.56) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7463673 | 0.81 | ALDH1A1 (0.53) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL20783375 | 0.80 | LMNA (0.63) | LMNAPLIN1PLIN5ABHD5USP9X | |
| SCHEMBL11995966 | 0.78 | PKM (0.62) | LMNAPLIN1PLIN5ABHD5USP9X | |
| SCHEMBL1315618 | 0.78 | USP9X (0.87) | LMNAPLIN1PLIN5ABHD5USP9X | |
| SCHEMBL30024196 | 0.78 | USP9X (0.87) | LMNAPLIN1PLIN5ABHD5USP9X | |
| SCHEMBL1315620 | 0.78 | USP9X (0.87) | LMNAPLIN1PLIN5ABHD5USP9X | |
| SCHEMBL7463147 | 0.77 | MCL1 (0.53) | LMNAMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | claimed |