SCHEMBL7470342

SCHEMBL7470342

N#CC(=Cc1cc2ccccc2cn1)C(=O)NCc1ccc(O)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.60
KMT2A Q03164 6/20 0.60
EGFR P00533 3/20 0.56
ERBB2 P04626 2/20 0.56
HSP90AA1 P07900 1/20 0.55
LMNA P02545 2/20 0.52
PLIN1 O60240 1/20 0.52
PLIN5 Q00G26 1/20 0.52
ABHD5 Q8WTS1 1/20 0.52
USP9X Q93008 1/20 0.52
ALDH1A1 P00352 2/20 0.51
HPGD P15428 2/20 0.51
KDM4E B2RXH2 2/20 0.51
MAPT P10636 2/20 0.51
EEF2K O00418 1/20 0.51
PLK4 O00444 1/20 0.51
PIM1 P11309 1/20 0.51
AXL P30530 1/20 0.51
MAPKAPK2 P49137 1/20 0.51
GSK3A P49840 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7470135 0.92 LMNA (0.62) MEN1KMT2AEGFRERBB2LMNA
SCHEMBL7463673 0.89 ALDH1A1 (0.53) MEN1KMT2AEGFRERBB2HSP90AA1
SCHEMBL7461493 0.83 MAPT (0.48) MEN1KMT2AEGFRERBB2LMNA
SCHEMBL7461370 0.81 ALDH1A1 (0.59) MEN1KMT2AEGFRERBB2HSP90AA1
SCHEMBL7467178 0.77 KMT2A (0.56) MEN1KMT2AEGFRERBB2LMNA
SCHEMBL7463147 0.75 MCL1 (0.53) MEN1KMT2AEGFRERBB2LMNA
SCHEMBL7463154 0.75 MCL1 (0.53) MEN1KMT2AEGFRERBB2LMNA
SCHEMBL7457358 0.74 MEN1 (0.60) MEN1KMT2AEGFRERBB2HSP90AA1
SCHEMBL7465717 0.74 MEN1 (0.54) MEN1KMT2AEGFRERBB2HSP90AA1
SCHEMBL20783375 0.73 LMNA (0.63) MEN1KMT2AEGFRERBB2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700388-B1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2002-09-18 EP claimed
EP-0700388-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1996-03-13 EP claimed
WO-1995026341-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA S.P.A. (IT) 1995-10-05 WO claimed
EP-0700388-B1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2002-09-18 EP disclosed
US-5652250-A TYROSINE KINASE INHIBITORS PHARMACIA S.P.A. (IT) 1997-07-29 US disclosed
EP-0700388-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1996-03-13 EP disclosed
WO-1995026341-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA S.P.A. (IT) 1995-10-05 WO disclosed