SCHEMBL7464015

SCHEMBL7464015

Clc1cccc2c(Oc3ccccc3I)ccnc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.47
KDM4E B2RXH2 8/20 0.41
ALDH1A1 P00352 6/20 0.41
SMN1; SMN2 Q16637 5/20 0.41
HTT P42858 5/20 0.40
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
TDP1 Q9NUW8 4/20 0.40
MAPK1 P28482 3/20 0.40
LMNA P02545 3/20 0.40
TP53 P04637 3/20 0.40
HSP90AA1 P07900 3/20 0.40
ALOX15 P16050 3/20 0.40
SLC6A2 P23975 3/20 0.40
USP2 O75604 2/20 0.40
CYP3A4 P08684 2/20 0.40
MAPT P10636 2/20 0.40
HPGD P15428 2/20 0.40
ALOX12 P18054 2/20 0.40
OPRK1 P41145 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7466638 0.88 NR4A2 (0.53) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7531657 0.87 NR4A2 (0.59) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7461220 0.82 NR4A2 (0.47) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7465295 0.82 KDM4E (0.58) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7471877 0.82 NR4A2 (0.47) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7464651 0.82 NR4A2 (0.47) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7464982 0.80 L3MBTL1 (0.46) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7458613 0.80 NR4A2 (0.54) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7468223 0.79 NR4A2 (0.47) NR4A2KDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL7466203 0.79 NR4A2 (0.44) NR4A2KDM4EALDH1A1SMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP claimed
US-5145843-A For plants DOWELANCO (US) 1992-09-08 US claimed
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP disclosed