Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478660 | 0.92 | DRD4 (0.63) | REV1ALDH1A1DRD4MEN1KMT2A | |
| SCHEMBL7471366 | 0.89 | CACNA1G (0.53) | REV1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7476648 | 0.80 | CACNA1G (0.59) | REV1ALDH1A1KDM4EDRD4MEN1 | |
| SCHEMBL7542659 | 0.77 | ALDH1A1 (0.60) | REV1ALDH1A1KDM4EDRD4MEN1 | |
| SCHEMBL3893619 | 0.75 | SMN1; SMN2 (0.61) | REV1ALDH1A1KDM4EDRD4MEN1 | |
| SCHEMBL7461499 | 0.74 | CACNA1G (0.57) | REV1MEN1KMT2ALMNAGAA | |
| SCHEMBL8218392 | 0.74 | HTR1A (0.67) | REV1ALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL6277857 | 0.74 | MEN1 (0.65) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL6269531 | 0.73 | TSHR (0.81) | REV1ALDH1A1KDM4EDRD4MEN1 | |
| SCHEMBL14207945 | 0.73 | REV1 (0.67) | REV1ALDH1A1KDM4EDRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |