Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ME2 | P23368 | 1/20 | 0.54 |
| ▸ | ME1 | P48163 | 1/20 | 0.54 |
| ▸ | ME3 | Q16798 | 1/20 | 0.54 |
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540046 | 0.85 | KMT2A (0.66) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL6269531 | 0.84 | TSHR (0.81) | ALDH1A1KDM4ETSHRLMNAGFER | |
| SCHEMBL2327539 | 0.84 | ALDH1A1 (0.64) | ALDH1A1KDM4ETSHRLMNAMEN1 | |
| SCHEMBL8556384 | 0.82 | MEN1 (0.60) | ALDH1A1KDM4ETSHRLMNAMEN1 | |
| SCHEMBL7478660 | 0.81 | DRD4 (0.63) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| SCHEMBL6261397 | 0.79 | ALOX15 (0.74) | ALDH1A1KDM4ETSHRLMNAMEN1 | |
| SCHEMBL26007622 | 0.79 | ALDH1A1 (0.58) | ALDH1A1KDM4ETSHRLMNAMEN1 | |
| Pyrrocaine SCHEMBL25718 | 0.79 | MEN1 (0.70) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2099004 | 0.78 | LMNA (0.62) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2096761 | 0.77 | MEN1 (0.73) | ALDH1A1KDM4ELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937054-B1 | 4-(1-PIPERAZINYL)BENZOIC ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATIONS | MERCK PATENT GMBH (DE) | 2002-06-05 | — | — | EP | claimed |
| US-6281215-B1 | TREATMENT OF DIABETES. | MERCK PATENT GMBH (DE) | 2001-08-28 | — | — | US | claimed |
| EP-0937054-A1 | 4-(1-PIPERAZINYL)BENZOIC ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATIONS | MERCK PATENT GmbH (DE) | 1999-08-25 | — | — | EP | claimed |
| WO-1998027078-A1 | NEW 4-(1-PIPERAZINYL)BENZOIC ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATIONS | MERCK PATENT GMBH (DE) | 1998-06-25 | — | — | WO | claimed |
| EP-0937054-B1 | 4-(1-PIPERAZINYL)BENZOIC ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATIONS | MERCK PATENT GMBH (DE) | 2002-06-05 | — | — | EP | disclosed |
| US-6281215-B1 | TREATMENT OF DIABETES. | MERCK PATENT GMBH (DE) | 2001-08-28 | — | — | US | disclosed |
| EP-0937054-A1 | 4-(1-PIPERAZINYL)BENZOIC ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATIONS | MERCK PATENT GmbH (DE) | 1999-08-25 | — | — | EP | disclosed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| WO-1998027078-A1 | NEW 4-(1-PIPERAZINYL)BENZOIC ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATIONS | MERCK PATENT GMBH (DE) | 1998-06-25 | — | — | WO | disclosed |