Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 6/20 | 0.90 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 3/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.64 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 3/20 | 0.63 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | PRKCA | P17252 | 2/20 | 0.57 |
| ▸ | BCR | P11274 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | CHUK | O15111 | 1/20 | 0.57 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903457 | 0.88 | MAPK8 (0.81) | CAMK2DMAPK8MAPK10GSK3BPIK3CG | |
| SCHEMBL4800404 | 0.86 | MAPK8 (0.83) | CAMK2DMAPK8MAPK10GSK3BPIK3CG | |
| SCHEMBL4062045 | 0.86 | CAMK2D (0.78) | CAMK2DMAPK8MAPK10GSK3BPIK3CG | |
| SCHEMBL210190 | 0.86 | ABL1 (0.76) | CAMK2DMAPK8MAPK10GSK3BPIK3CG | |
| Hydrochloric Acid SCHEMBL7470853 | 0.85 | ABL1 (0.74) | CAMK2DMAPK8MAPK10GSK3BPIK3CG | |
| SCHEMBL4902223 | 0.84 | ABL1 (0.80) | CAMK2DMAPK8GSK3BPIK3CGCAMKK2 | |
| SCHEMBL4903404 | 0.83 | JAK2 (0.68) | CAMK2DMAPK8MAPK10JAK2JAK3 | |
| SCHEMBL7470875 | 0.82 | PLK1 (0.63) | CAMK2DMAPK8MAPK10PIK3CGAURKA | |
| SCHEMBL7470447 | 0.82 | JAK2 (0.79) | CAMK2DJAK2JAK3ABL1BCR | |
| SCHEMBL3949136 | 0.82 | CAMK2D (0.66) | CAMK2DMAPK8MAPK10GSK3BPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |