Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463880 | 0.88 | ALOX15 (0.51) | ADRA1DADRA1AADRA1BDRD2ADRA2B | |
| Hydrochloric Acid SCHEMBL7459572 | 0.87 | ALOX15 (0.52) | ADRA1DADRA1AADRA1BADRA2BADRA2A | |
| SCHEMBL10677091 | 0.80 | ADRA2A (0.59) | ADRA1DADRA1AADRA1BDRD2KDM4E | |
| SCHEMBL7471577 | 0.80 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BADRA2BADRA2A | |
| SCHEMBL7464688 | 0.79 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BDRD2 | |
| Hydrochloric Acid SCHEMBL8124829 | 0.79 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BADRA2BADRA2A | |
| SCHEMBL7475295 | 0.78 | ADRA2B (0.48) | ADRA1DADRA1AADRA1BADRA2BADRA2A | |
| SCHEMBL7473732 | 0.78 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BADRA2BADRA2A | |
| Hydrochloric Acid SCHEMBL8131925 | 0.77 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BADRA2BADRA2A | |
| SCHEMBL7463668 | 0.76 | SMN1; SMN2 (0.63) | ADRA1DADRA1AADRA1BADRA2BADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198234-A2 | BICYCLIC AROMATIC COMPOUNDS FOR TREATING DRUG ADDICTION | Knoll GmbH (DE) | 2002-04-24 | — | — | EP | claimed |
| WO-2001002391-A2 | BICYCLIC AROMATIC COMPOUNDS FOR TREATING DRUG ADDICTION | KNOLL GMBH (DE) | 2001-01-11 | — | — | WO | claimed |
| EP-0717739-B1 | 1,4-Benzodioxane derivatives having affinity for D2 receptors and utility in the treatment of psychoses | KNOLL AG (DE) | 2000-03-29 | — | — | EP | claimed |
| EP-0717739-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-06-26 | — | — | EP | claimed |
| WO-1995007274-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-03-16 | — | — | WO | claimed |
| EP-1198234-A2 | BICYCLIC AROMATIC COMPOUNDS FOR TREATING DRUG ADDICTION | Knoll GmbH (DE) | 2002-04-24 | — | — | EP | disclosed |
| WO-2001002391-A2 | BICYCLIC AROMATIC COMPOUNDS FOR TREATING DRUG ADDICTION | KNOLL GMBH (DE) | 2001-01-11 | — | — | WO | disclosed |
| EP-0717739-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007274-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-03-16 | — | — | WO | disclosed |