Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589363 | 0.98 | PPARG (0.51) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7397016 | 0.97 | PPARG (0.50) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| SCHEMBL4587500 | 0.91 | HTR7 (0.52) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| SCHEMBL8742206 | 0.91 | PPARG (0.51) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| Paliroden SCHEMBL4587135 | 0.90 | HTR7 (0.53) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| Paliroden SCHEMBL29375649 | 0.90 | HTR7 (0.53) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| SCHEMBL9485644 | 0.90 | PPARG (0.53) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7393191 | 0.90 | MAOB (0.53) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| Bromide SCHEMBL8742395 | 0.90 | PPARG (0.50) | PPARGPPARAHTR7CYP1A2CYP3A4 | |
| SCHEMBL9501239 | 0.90 | SIGMAR1 (0.55) | PPARGPPARAHTR7MAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837848-B1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI SYNTHELABO (FR) | 2002-09-11 | — | — | EP | disclosed |
| EP-1216996-A2 | Method to synthesise biphenylyl derivatives | SANOFI-SYNTHELABO (FR) | 2002-06-26 | — | — | EP | disclosed |
| EP-0837848-A1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI (FR) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997001536-A1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI (FR) | 1997-01-16 | — | — | WO | disclosed |