Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 12/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466216 | 0.93 | P2RY12 (0.47) | P2RY12CYP3A4CYP2C9GPR119MAPT | |
| SCHEMBL7469874 | 0.84 | GRIK1 (0.51) | — | |
| SCHEMBL7523406 | 0.78 | GRIK1 (0.54) | — | |
| SCHEMBL3456352 | 0.76 | KDM4E (0.52) | MAPTKDM4EKMT2AHSD17B10 | |
| SCHEMBL7459836 | 0.74 | HRH3 (0.52) | MAPTKDM4EKMT2ATDP1HSD17B10 | |
| SCHEMBL11010057 | 0.73 | ALDH1A1 (0.56) | CYP2C9KDM4EKMT2A | |
| SCHEMBL14217003 | 0.70 | MAPK1 (0.52) | MAPTKDM4EKMT2A | |
| SCHEMBL9638662 | 0.70 | ALDH1A1 (0.44) | P2RY12MAPTKDM4E | |
| SCHEMBL2824291 | 0.68 | NLRP3 (0.55) | CYP2C9MAPTKDM4EKMT2A | |
| SCHEMBL29649051 | 0.68 | NLRP3 (0.55) | CYP2C9MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |