Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777743 | 0.78 | KDM4E (0.66) | KDM4EHSD17B10HPGDSRD5A2MAPT | |
| SCHEMBL3700465 | 0.78 | KDM4E (0.66) | KDM4EHSD17B10HPGDSRD5A2MAPT | |
| SCHEMBL7475485 | 0.78 | MMP12 (0.42) | KDM4EALOX5KMT2AALDH1A1NFKB1 | |
| SCHEMBL5733671 | 0.74 | RAB9A (0.62) | KDM4EHPGDMAPTFLT3PDGFRB | |
| SCHEMBL980203 | 0.74 | TNKS (0.66) | KDM4EALOX5KMT2AALDH1A1NFKB1 | |
| SCHEMBL5945621 | 0.73 | PRKAG1 (0.51) | KDM4EALOX5KMT2AALDH1A1NFKB1 | |
| SCHEMBL6518508 | 0.73 | KDM4E (0.72) | KDM4EHSD17B10HPGDSRD5A2MAPT | |
| Indole-2-Carboxylic Acid SCHEMBL29395165 | 0.73 | KDM4E (1.00) | KDM4EHSD17B10HPGDSRD5A2MAPT | |
| Indole-2-Carboxylic Acid SCHEMBL1935 | 0.73 | KDM4E (1.00) | KDM4EHSD17B10HPGDSRD5A2MAPT | |
| SCHEMBL27350271 | 0.73 | DAO (0.50) | KDM4EHSD17B10HPGDSRD5A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656360-B1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN SEIYAKU KK (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-5629430-A | ANTICARCINOGENIC AGENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0656360-A1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |