Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602741 | 0.91 | CHEK2 (0.57) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL828113 | 0.81 | KDM4E (0.56) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7476359 | 0.80 | CHEK2 (0.50) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL4366407 | 0.79 | NR4A2 (0.65) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL5217712 | 0.78 | CHEK2 (0.71) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7470356 | 0.77 | TDP1 (0.48) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7469217 | 0.77 | CHEK2 (0.47) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7461639 | 0.75 | MMP2 (0.64) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7471440 | 0.75 | CHEK2 (0.45) | CHEK2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL8611572 | 0.75 | RAB9A (0.64) | CHEK2KDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |