Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470642 | 0.91 | SIGMAR1 (0.35) | SIGMAR1HTR2AHTR2CHTR1ADRD3 | |
| SCHEMBL7473374 | 0.86 | SIGMAR1 (0.46) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL7468538 | 0.81 | HTR1A (0.55) | SIGMAR1HTR2AHTR2CHTR1ADRD4 | |
| SCHEMBL7477921 | 0.80 | DRD2 (0.50) | HTR2AHTR2CHTR1ADRD2DRD4 | |
| SCHEMBL7477641 | 0.80 | DRD2 (0.48) | HTR1ADRD2 | |
| SCHEMBL7472531 | 0.79 | SIGMAR1 (0.42) | SIGMAR1HTR1A | |
| SCHEMBL7473274 | 0.79 | DRD2 (0.51) | SIGMAR1HTR2AHTR2CHTR1ADRD2 | |
| SCHEMBL7466677 | 0.79 | SIGMAR1 (0.39) | SIGMAR1HTR1A | |
| SCHEMBL7477337 | 0.78 | HTR1A (0.36) | HTR1ADRD3 | |
| SCHEMBL7476677 | 0.77 | HTR1A (0.38) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755930-B1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6337397-B1 | A BENZOXAZEPINE DERIVATIVE FOR TREATMENT OF ANXIETY NEUROSIS, PHOBIAS, OBSESSIVE-COMPULSIVE DISORDERS, SCHIZOPHRENIA, POST-CARDIAC TRAUMA STRESS DISORDERS, DEPRESSION DISORDERS, PSYCHOSOMATIC DISORDERS AND OTHER PSYCHONEUROTIC DISORDERS, | SUNTORY LIMITED (JP) | 2002-01-08 | — | — | US | disclosed |
| US-6187769-B1 | Benzoxazepine derivatives and their salts and medicaments containing the same | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0755930-A1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |