Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477641 | 0.91 | DRD2 (0.48) | HTR1AHRH3 | |
| SCHEMBL7469171 | 0.86 | KCNH2 (0.50) | HTR1AHTR2AHTR2CDRD4DRD3 | |
| SCHEMBL7670715 | 0.86 | KCNH2 (0.56) | HTR1AHTR2ADRD3HTR7KCNH2 | |
| SCHEMBL7477921 | 0.84 | DRD2 (0.50) | HTR1AHTR2AHTR2CDRD4DRD3 | |
| SCHEMBL7473274 | 0.83 | DRD2 (0.51) | HTR1AHTR2AHTR2CSIGMAR1DRD4 | |
| SCHEMBL7476626 | 0.83 | HTR1A (0.57) | HTR1AHTR2AHTR2CSIGMAR1DRD4 | |
| SCHEMBL7467438 | 0.83 | HTR1A (0.55) | HTR1AHTR2AHTR2CSIGMAR1DRD4 | |
| SCHEMBL7467487 | 0.82 | HTR1A (0.53) | HTR1AHTR2ADRD3HTR7KCNH2 | |
| SCHEMBL7466343 | 0.81 | SIGMAR1 (0.37) | HTR1AHTR2AHTR2CSIGMAR1DRD4 | |
| SCHEMBL7473374 | 0.81 | SIGMAR1 (0.46) | HTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755930-B1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6337397-B1 | A BENZOXAZEPINE DERIVATIVE FOR TREATMENT OF ANXIETY NEUROSIS, PHOBIAS, OBSESSIVE-COMPULSIVE DISORDERS, SCHIZOPHRENIA, POST-CARDIAC TRAUMA STRESS DISORDERS, DEPRESSION DISORDERS, PSYCHOSOMATIC DISORDERS AND OTHER PSYCHONEUROTIC DISORDERS, | SUNTORY LIMITED (JP) | 2002-01-08 | — | — | US | disclosed |
| US-6187769-B1 | Benzoxazepine derivatives and their salts and medicaments containing the same | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0755930-A1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |