SCHEMBL7467936

SCHEMBL7467936

NC(=O)C1(c2cccnc2)CCNCC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 2/20 0.45
OPRL1 P41146 1/20 0.45
ITGA4 P13612 1/20 0.43
ITGB7 P26010 1/20 0.43
F7 P08709 1/20 0.41
F3 P13726 1/20 0.41
SARM1 Q6SZW1 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.41
SIRT6 Q8N6T7 1/20 0.41
SIRT1 Q96EB6 1/20 0.41
SIRT3 Q9NTG7 1/20 0.41
SIRT5 Q9NXA8 1/20 0.41
SIRT4 Q9Y6E7 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
ALDH1A1 P00352 4/20 0.40
LMNA P02545 1/20 0.40
MKNK1 Q9BUB5 3/20 0.38
MKNK2 Q9HBH9 3/20 0.38
HCAR2 Q8TDS4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8347400 0.98 OPRM1 (0.44) OPRM1OPRL1ITGA4ITGB7F7
SCHEMBL10002454 0.89 OPRM1 (0.49) OPRM1OPRL1F7F3SARM1
SCHEMBL8302463 0.86 ITGA4 (0.46) OPRM1ITGA4ITGB7MEN1KMT2A
SCHEMBL31091550 0.86 OPRM1 (0.47) OPRM1OPRL1F7F3SARM1
SCHEMBL89653 0.86 OPRM1 (0.47) OPRM1OPRL1ITGA4ITGB7F7
SCHEMBL15348892 0.86 OPRM1 (0.47) OPRM1OPRL1F7F3SARM1
Hydrochloric Acid SCHEMBL8350428 0.85 ITGA4 (0.45) OPRM1ITGA4ITGB7MEN1KMT2A
SCHEMBL3664975 0.84 LMNA (0.47) OPRM1OPRL1ITGA4ITGB7F7
SCHEMBL15823293 0.84 LMNA (0.47) OPRM1OPRL1ITGA4ITGB7F7
SCHEMBL8636689 0.81 OPRM1 (0.41) OPRM1OPRL1KMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1119344-C Heterocyclic substed. pyrrolidine amide derivs. AVENTIS PHARMA INC (US) 2003-08-27 CN disclosed
EP-0946548-B1 NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES AVENTIS PHARMA INC (US) 2002-03-06 EP disclosed
CN-1241185-A Novel heterocyclic substituted pyrrolidine amide derivatives HOECHST MARION ROUSSEL INC (US) 2000-01-12 CN disclosed
EP-0946548-A1 NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-10-06 EP disclosed
US-5861417-A TACHYKININ RECEPTOR ANTAGONISTS USEFUL IN TREATING ASTHMA, COUGH, BRONCHITIS, PAIN HOECHST MARION ROUSSEL, INC. (US) 1999-01-19 US disclosed
US-5824690-A TREATING ASTHMA, COUGH HOECHST MARION ROUSSEL INC. (US) 1998-10-20 US disclosed
WO-1998027086-A1 NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1998-06-25 WO disclosed