Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623986 | 0.78 | ALDH1A1 (1.00) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7471769 | 0.78 | ALDH1A1 (0.44) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7468872 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL27605206 | 0.76 | SMN1; SMN2 (0.74) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7467894 | 0.76 | ABL1 (0.48) | NPC1MAPTMEN1KMT2ACYP19A1 | |
| SCHEMBL5277507 | 0.73 | KCNH2 (0.50) | KDM4EALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL2068779 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7462995 | 0.72 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2NPC1MEN1 | |
| SCHEMBL28135933 | 0.72 | SMN1; SMN2 (0.73) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL3225225 | 0.71 | ALDH1A1 (0.64) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |