SCHEMBL746936

SCHEMBL746936

COc1ccc(C=CC=O)c(OC)c1OC

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.57
CYP1A1 P04798 6/20 0.56
CYP1B1 Q16678 6/20 0.56
CYP19A1 P11511 1/20 0.54
CYP1A2 P05177 5/20 0.50
MAPT P10636 3/20 0.50
CYP2D6 P10635 2/20 0.50
ALDH1A1 P00352 2/20 0.50
POLB P06746 1/20 0.50
KMT2A Q03164 1/20 0.50
NPC1 O15118 1/20 0.49
LMNA P02545 1/20 0.49
TP53 P04637 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
CHRNA7 P36544 1/20 0.46
CYP3A4 P08684 1/20 0.46
NFE2L2 Q16236 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7198703 1.00 ABCG2 (0.57) ABCG2CYP1A1CYP1B1CYP19A1CYP1A2
SCHEMBL8494360 0.84 NFE2L2 (0.63) CYP1A1CYP1B1CYP19A1CYP1A2MAPT
SCHEMBL2119793 0.84 NFE2L2 (0.63) CYP1A1CYP1B1CYP19A1CYP1A2MAPT
SCHEMBL5451938 0.81 XDH (0.44) ABCG2CYP1A1CYP1B1CYP1A2MAPT
SCHEMBL8502492 0.81 CYP1A1 (0.56) ABCG2CYP1A1CYP1B1CYP19A1CYP1A2
SCHEMBL8502491 0.81 CYP1A1 (0.56) ABCG2CYP1A1CYP1B1CYP19A1CYP1A2
SCHEMBL31474876 0.80 ALDH1A1 (0.56) ABCG2CYP1A1CYP1B1CYP19A1CYP1A2
SCHEMBL269268 0.80 ALDH1A1 (0.56) ABCG2CYP1A1CYP1B1CYP19A1CYP1A2
SCHEMBL28285216 0.80 XDH (0.50) ABCG2CYP1A1CYP1B1CYP1A2MAPT
Formaldehyde SCHEMBL5462063 0.79 XDH (0.41) ABCG2CYP1A1CYP1B1CYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2429292-A1 COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR THE TREATMENT OF CANCER Georgia State University Research Foundation, Inc. (US) 2012-03-21 EP claimed
WO-2010129858-A1 COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR THE TREATMENT OF CANCER GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) 2010-11-11 WO claimed
EP-3959189-B1 METHOD OF DEPOLYMERISING PHENOLIC POLYMERS UNIV STELLENBOSCH (ZA) 2026-01-28 EP disclosed
US-12275697-B2 Method of depolymerising phenolic polymers STELLENBOSCH UNIVERSITY (ZA) 2025-04-15 US disclosed
US-20220227694-A1 Method of Depolymerising Phenolic Polymers STELLENBOSCH UNIVERSITY (ZA) 2022-07-21 US disclosed
EP-3959189-A1 METHOD OF DEPOLYMERISING PHENOLIC POLYMERS Stellenbosch University (ZA) 2022-03-02 EP disclosed
WO-2020217209-A1 METHOD OF DEPOLYMERISING PHENOLIC POLYMERS STELLENBOSCH UNIVERSITY (ZA) 2020-10-29 WO disclosed
WO-2008156654-A2 CYTOSKELETON MODULATORS FOR TREATING METABOLIC DISORDERS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2008-12-24 WO disclosed
US-6566557-B2 Oxidation of a phenylpropane compound COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2003-05-20 US disclosed
US-20020133045-A1 Process for the preparation of substituted trans-cinnamaldehyde, a natural yellow dye, from phenylpropane derivatives COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2002-09-19 US disclosed
WO-2002072709-A1 A PROCESS FOR THE PREPARATION OF SUBSTITUTED TRANS-CINNAMALDEHYDE, A NATURAL YELLOW DYE, FROM PHENYLPROPANE DERIVATIVES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2002-09-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220227694-A1 Method of Depolymerising Phenolic Polymers DCXR, GRHPR, HPD ABCG2 2718/4885CYP1A1 1803/4885CYP1B1 2444/4885
US-12275697-B2 Method of depolymerising phenolic polymers DCXR, GRHPR, HPD ABCG2 2718/4885CYP1A1 1803/4885CYP1B1 2444/4885
US-20020133045-A1 Process for the preparation of substituted trans-cinnamaldehyde, a natural yellow dye, from phenylpropane derivatives CBR3, DDT, DHODH ABCG2 962/4885CYP1A1 881/4885CYP1B1 1708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.