Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4455366 | 0.96 | NOD1 (0.38) | LMNAAPOBEC3AAPOBEC3GPPARGPPARA | |
| Iodide SCHEMBL7467982 | 0.91 | PPARG (0.39) | PPARGPPARAPPARDNOD1NOD2 | |
| Iodide SCHEMBL7466546 | 0.91 | MAT2A (0.34) | LMNAAPOBEC3AAPOBEC3GHTT | |
| Bromide SCHEMBL7469454 | 0.88 | PSEN1 (0.38) | LMNAPPARGPPARAPPARDNOD1 | |
| Iodide SCHEMBL7464172 | 0.85 | GAA (0.35) | NOD1NOD2KDM4EALDH1A1HPGD | |
| SCHEMBL8784743 | 0.85 | ALDH3A1 (0.43) | LMNAPPARGPPARAPPARDNOD1 | |
| Iodide SCHEMBL7462206 | 0.84 | CMA1 (0.38) | LMNAAPOBEC3AAPOBEC3GPPARGPPARA | |
| Bromide SCHEMBL4450841 | 0.82 | PSEN1 (0.35) | PPARGPPARANOD1NOD2PSEN1 | |
| SCHEMBL7457272 | 0.81 | NOD1 (0.37) | LMNAPPARGPPARAPPARDNOD1 | |
| SCHEMBL7472829 | 0.80 | CMA1 (0.45) | LMNAPPARGPPARDNOD1NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |