Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472633 | 0.86 | MAPT (0.36) | GAAKDM4EALDH1A1GLAHPGD | |
| Iodide SCHEMBL7469544 | 0.85 | LMNA (0.37) | NOD2NOD1KDM4EALDH1A1HPGD | |
| Iodide SCHEMBL4455366 | 0.84 | NOD1 (0.38) | NOD2NOD1KDM4EALDH1A1HPGD | |
| Iodide SCHEMBL7467982 | 0.82 | PPARG (0.39) | NOD2NOD1 | |
| Iodide SCHEMBL7466546 | 0.81 | MAT2A (0.34) | — | |
| Iodide SCHEMBL7464178 | 0.81 | MAPT (0.37) | GAAKDM4EALDH1A1 | |
| SCHEMBL7467186 | 0.81 | NOD1 (0.36) | GAANOD2NOD1KDM4EALDH1A1 | |
| SCHEMBL8705102 | 0.78 | GAA (0.38) | GAANOD2NOD1KDM4EHPGD | |
| Bromide SCHEMBL7469454 | 0.75 | PSEN1 (0.38) | NOD2NOD1KDM4EALDH1A1HPGD | |
| SCHEMBL7467945 | 0.75 | AKR1B1 (0.39) | GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |