Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474842 | 0.86 | RXFP1 (0.62) | EGFRMAPK1KDM4EALDH1A1AURKA | |
| SCHEMBL7465660 | 0.86 | EGFR (0.56) | EGFRMAPK1KDM4EALDH1A1AURKA | |
| SCHEMBL8825686 | 0.85 | EGFR (0.52) | EGFRFYNSRCMAPK1KDM4E | |
| SCHEMBL7470465 | 0.84 | MAPK1 (0.66) | EGFRMAPK1KDM4EALDH1A1RXFP1 | |
| SCHEMBL7475194 | 0.84 | EGFR (0.66) | EGFRMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL18334804 | 0.82 | EGFR (0.70) | EGFRFYNSRCALDH1A1AURKA | |
| SCHEMBL7470683 | 0.81 | KDM4E (0.61) | EGFRMAPK1KDM4EALDH1A1AURKA | |
| SCHEMBL7469700 | 0.81 | EGFR (0.54) | EGFRMAPK1KDM4EALDH1A1PRKCQ | |
| SCHEMBL7470191 | 0.80 | EGFR (0.48) | EGFRFYNSRCAURKARPS6KB1 | |
| SCHEMBL7473179 | 0.79 | MAPK1 (0.58) | EGFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |