Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461530 | 0.89 | PKM (0.56) | KDM4EALDH1A1HPGDEGFRPKM | |
| SCHEMBL7475194 | 0.85 | EGFR (0.66) | KDM4EHPGDEGFRMAPK1LMNA | |
| SCHEMBL8825812 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1HPGDEGFRCTSB | |
| SCHEMBL7474842 | 0.82 | RXFP1 (0.62) | KDM4EALDH1A1HPGDEGFRMAPK1 | |
| SCHEMBL7465660 | 0.82 | EGFR (0.56) | KDM4EALDH1A1EGFRMAPK1MAPT | |
| SCHEMBL7473179 | 0.81 | MAPK1 (0.58) | EGFRMAPK1MAPTLMNA | |
| SCHEMBL7469892 | 0.81 | EGFR (0.55) | KDM4EALDH1A1EGFRMAPK1AURKA | |
| SCHEMBL21835307 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HPGDEGFRCTSB | |
| SCHEMBL7457697 | 0.80 | EGFR (0.62) | EGFRMAPTGAAKMT2A | |
| SCHEMBL7472725 | 0.80 | EGFR (0.61) | EGFRMAPK1AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |