Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474800 | 0.85 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAWDR5SMN1; SMN2 | |
| SCHEMBL8119812 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAWDR5MEN1 | |
| SCHEMBL7464017 | 0.79 | MAPT (0.52) | ALDH1A1MAPTLMNAWDR5MEN1 | |
| SCHEMBL7467872 | 0.79 | EIF2AK2 (0.55) | ALDH1A1LMNAWDR5MEN1KMT2A | |
| SCHEMBL18406809 | 0.79 | ALDH1A1 (0.39) | ALDH1A1MAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL7471594 | 0.77 | NR1H3 (0.47) | ALDH1A1MAPTLMNAWDR5MEN1 | |
| SCHEMBL5637927 | 0.77 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL5783473 | 0.76 | ENPP2 (0.51) | ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL16549301 | 0.74 | ALDH1A1 (0.57) | ALDH1A1MAPTLMNASMN1; SMN2IDE | |
| SCHEMBL7480479 | 0.74 | NCF1 (0.62) | ALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |