Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | USP10 | Q14694 | 1/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.54 |
| ▸ | USP13 | Q92995 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468656 | 0.92 | HTT (0.67) | HTTUSP10PIK3C3USP13NTRK1 | |
| SCHEMBL7469214 | 0.83 | USP10 (0.76) | HTTUSP10PIK3C3USP13EGFR | |
| SCHEMBL7470038 | 0.82 | HTT (0.45) | HTTUSP10PIK3C3USP13PIK3CD | |
| SCHEMBL7464247 | 0.82 | HTT (0.74) | HTTPIK3CDPIK3R1NTRK1AURKA | |
| SCHEMBL7474381 | 0.81 | PDE5A (0.61) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13171085 | 0.81 | HTT (0.67) | HTTUSP10PIK3C3USP13PIK3CD | |
| SCHEMBL9921421 | 0.81 | PIK3CD (0.70) | HTTUSP10PIK3C3USP13PIK3CD | |
| SCHEMBL13191860 | 0.81 | HTT (0.86) | HTTUSP10PIK3C3USP13PIK3CD | |
| SCHEMBL7470175 | 0.81 | PIK3CD (0.50) | HTTPIK3CDPIK3R1NTRK1EGFR | |
| SCHEMBL9921433 | 0.79 | HTT (0.64) | HTTUSP10PIK3C3USP13PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |