Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469778 | 0.84 | MAPT (0.45) | MAPTALDH1A1POLBACHEBACE1 | |
| SCHEMBL7475788 | 0.81 | MAPT (0.40) | MAPTALDH1A1POLBACHEBACE1 | |
| SCHEMBL7468270 | 0.81 | MAPT (0.40) | MAPTALDH1A1POLBACHEBACE1 | |
| SCHEMBL7469735 | 0.80 | LMNA (0.47) | MAPTALDH1A1POLBACHEBACE1 | |
| SCHEMBL7469896 | 0.80 | EGFR (0.46) | MAPTALDH1A1SIGMAR1LMNA | |
| SCHEMBL7459038 | 0.79 | MAPT (0.43) | MAPTALDH1A1ACHEBACE1HTR6 | |
| SCHEMBL7475558 | 0.78 | MAPT (0.43) | MAPTALDH1A1ACHEBACE1NCF1 | |
| SCHEMBL7468284 | 0.78 | MAPT (0.43) | MAPTALDH1A1POLBACHEBACE1 | |
| SCHEMBL7462130 | 0.78 | MAPT (0.42) | MAPTALDH1A1ACHEBACE1CYP1A2 | |
| SCHEMBL7470191 | 0.76 | EGFR (0.48) | MAPTACHEHTR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |