Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.53 |
| ▸ | PDE5A | O76074 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467508 | 0.90 | MAPK1 (0.52) | MAPK1SMN1; SMN2HTTEGFRCLK4 | |
| SCHEMBL7474668 | 0.89 | HTT (0.63) | MAPK1SMN1; SMN2HTTEGFRPDE5A | |
| SCHEMBL8825746 | 0.87 | HTT (0.62) | MAPK1SMN1; SMN2HTTEGFRRAF1 | |
| SCHEMBL7475194 | 0.85 | EGFR (0.66) | MAPK1SMN1; SMN2HTTEGFRLMNA | |
| SCHEMBL7473060 | 0.85 | STAT1 (0.64) | MAPK1SMN1; SMN2HTTEGFRRAF1 | |
| SCHEMBL7469106 | 0.85 | CLK4 (0.58) | MAPK1HTTEGFRRAF1CLK4 | |
| SCHEMBL7470701 | 0.82 | PDE5A (0.56) | MAPK1HTTEGFRRAF1PDE5A | |
| SCHEMBL7475448 | 0.82 | EGFR (0.56) | SMN1; SMN2HTTEGFRLMNA | |
| SCHEMBL7465009 | 0.81 | HTT (0.57) | MAPK1HTTEGFRLMNAMEN1 | |
| SCHEMBL7463395 | 0.81 | HTT (0.55) | MAPK1SMN1; SMN2HTTEGFRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |